Endocrine Abstracts

Introduction: The management of Craniopharyngioma is associated with significant long-term morbidity. We retrospectively assessed the endocrine, hypothalamic and neuro-developmental morbidity (at most recent clinic review) in survivors of Craniopharyngioma diagnosed between 1/01/98 and 31/12/09, and currently being managed at our centre.Methods: We identified 63 patients in our cohort of which 25 were randomly selected for analysis (11 males, 14 females)...

Background: CLDN14 gene encodes a protein involved in regulation of paracellular permeability or ion transport at epithelial tight junctions as in the nephron. C allele of the rs219780 SNP of CLDN14 gene has been associated with high levels of PTH and with low bone mineral density (BMD) in women. Our aim is to study the relationship between rs219780 SNP of CLDN14 and fractures, renal lithiasis and bone mineral density in patients with primary hyperparathyr...

Introduction/background: Hypothalamic Amenorrhea (HA), or stress-induced anovulation, is one of the most common causes of secondary amenorrhea (1,2) and accounts for the reproductive dysfunction seen in under nutrition, excessive exercise, sever emotional stress and chronic disease. From a teleological standpoint, in the face of nutritional or physical stress, it is adaptive for an organism to allocate energy resources for its own survival rather than the costly process of rep...

The finding of an adrenal incidentaloma warrants a careful diagnostic work-up to assess hormonal activity and potential malignancy. Current diagnostic algorithms depend largely on imaging studies, which is time-consuming, expensive and carries a health risk. Urinary steroid profiling using gas chromatography/mass spectrometry (GC/MS) might be a valuable diagnostic test for differentiating benign from malignant adrenal lesions, as adrenocortical carcinomas (ACC) often cause abn...

Introduction: Leptin seems to be a major link between obesity and thyroid dysfunction.Design: To analyze the relationship between thyrotropin (TSH) and leptin (LP) plasma concentrations and body mass index (BMI), in 785 subjects (448 women) of 41.27±9.72 years and BMI 28.91±9.8 (18.04–93.98 kg/m2), without diagnosed thyroid disease or pregnancy, concentrations of TSH, free thyroxine (FT4), LP, glycemia and insulinemia...

Introduction: The clinical significance of subclinical thyroid diseases is debated.Design: To assess the relationship between undiagnosed subclinical hypothyroidism (USH), health indicators (HI) and cardiovascular risk factors (CVRF), this cross-sectional study was conducted in 1100 adults representatives of non-institutionalized Catalan population (44.5% men; mean age: 44.8±15.2 years) in Catalonia (Spain); 40 USH (18 men) and 1060 euthyroid (474 m...

Background: Premature pubic hair development, with or without manifestations of androgen production, is a common clinical presentation. Premature adrenarche (PA) needs to be differentially diagnosed from congenital adrenal hyperplasia (CAH) and may be associated with early development of puberty.Aim: To study the characteristics at presentation, endocrine profile and outcome of patients who presented with premature pubic hair development. We studied retr...

Introduction: The Autoimmune Polyendocrinopathy Syndromes (APS) comprise 4 clinical subtypes (1–4), APS type 1 is an autosomal recessive disorder caused by mutations in the AIRE (Autoimmune Regulator) gene. It should include at least 2 of the following 3 major criteria: chronic mucocutaneous candidiasis (CMC), hypoparathyroidism (HPT) and adrenal insufficiency (AI) although 50% of patients develop all 3 features, usually before the age of 20 years. In addition, there are ...

Introduction: There is a large body of evidence to suggest that the GH axis plays an important role in brain myelination. However, results from studies in humans with an abnormal GH axis have varied and therefore there remains no consensus as to whether the GH/IGF1 axis plays a significant role in neural development. No previous studies have used diffusion tensor imaging (DTI) a sensitive magnetic resonance imaging (MRI) technique for studying brain white matter tracts, to add...

In chronic diseases patient (pat) often need continuous med treatment. In acromegaly and neuroendocrine tumors (GEP-NET), long term monthly injections of somatostatin analogues as Sandostatin® LAR® (SA®) are the treatment of choice. Problems regarding pat management and drug application might arise in not-specialized centers such as general practicioners (GP). To optimize pat’ management and compliance a homecare project* wa...